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- AGTR1 Antibodies
Proteintech
View all (19) AGTR1 antibodies
Cite AGTR1 Polyclonal Antibody
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AGTR1 Antibody (25343-1-AP) in IHC (P)
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 25343-1-AP (AGTR1 Antibody) at dilution of 1:50 (under 40x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Product Details
25343-1-AP
Applications
Tested Dilution
Publications
Western Blot(WB)
1:500-1:2,000
View 34 publications34 publications
Immunohistochemistry (IHC)
-
View 11 publications11 publications
Immunohistochemistry (Paraffin) (IHC (P))
1:20-1:200
-
Immunocytochemistry(ICC/IF)
-
View 6 publications6 publications
Immunoprecipitation(IP)
-
View 3 publications3 publications
Product Specifications
Species Reactivity
Human,Mouse,Rat
Published species
Human,Mouse,Rat
Host/Isotype
Rabbit/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AGTR1 Fusion Protein Ag14461 (290-359 aa encoded by BC022447)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IAYFNNCLN PLFYGFLGKK FKRYFLQLLK YIPPKAKSHS NLSTKMSTLS YRHSDNVSSS TKKPAPCFEV E (290-359 aa encoded by BC022447)
Target Information
AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases:angiotensin II receptor, type 1; Angiotensin II type-1 receptor; Angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; AT1 receptor; AT1 receptor A; AT1AR; AT1BR; Type-1 angiotensin II receptor; Type-1 angiotensin II receptor A; type-1A angiotensin II receptor; type-1B angiotensin II receptor; vascular type-1 angiotensin II receptor
Gene Aliases:1810074K20Rik; AG2S; Agtr-1a; AGTR1; AGTR1A; AGTR1B; AI551199; Angtr-1a; AT1; AT1A; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R
UniProt ID:(Human) P30556, (Rat) P25095, (Mouse) P29754
Entrez Gene ID:(Human) 185, (Rat) 24180, (Mouse) 11607
Function(s)
angiotensin type I receptor activityangiotensin type II receptor activityprotein bindingbradykinin receptor bindingprotein heterodimerization activityG-protein alpha-subunit bindingpeptide hormone bindingprotein kinase bindingD1 dopamine receptor bindingprotein self-associationsignal transducer activityG-protein coupled receptor activityG-protein coupled receptor
Process(es)
regulation of cell growthkidney developmentrenin-angiotensin regulation of aldosterone productionregulation of blood vessel size by renin-angiotensinregulation of systemic arterial blood pressure by renin-angiotensinG-protein coupled receptor signaling pathwayphospholipase C-activating G-protein coupled receptor signaling pathwaypositive regulation of cytosolic calcium ion concentrationRho protein signal transductionpositive regulation of macrophage derived foam cell differentiationpositive regulation of cholesterol esterificationregulation of vasoconstrictioncalcium-mediated signalingpositive regulation of cellular protein metabolic processpositive regulation of phospholipase A2 activitypositive regulation of NAD(P)H oxidase activitylow-density lipoprotein particle remodelingregulation of renal sodium excretionangiotensin-activated signaling pathwayregulation of cell proliferationregulation of vasodilationregulation of inflammatory responsepositive regulation of inflammatory responsepositive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaycell chemotaxisphospholipase C-activating angiotensin-activated signaling pathwaypositive regulation of reactive oxygen species metabolic processblood vessel developmentpositive regulation of receptor recyclingregulation of systemic arterial blood pressure by circulatory renin-angiotensinrenin secretion into blood streamregulation of renal output by angiotensinbrain renin-angiotensin systemregulation of pHinflammatory responseheart developmentagingregulation of blood pressurepositive regulation of cell proliferationpositive regulation of superoxide anion generationregulation of smooth muscle cell apoptotic processnegative regulation of smooth muscle cell apoptotic processvasoconstrictiondopamine biosynthetic processdrinking behavioractivation of Janus kinase activitynegative regulation of neuron apoptotic processresponse to estrogenpositive regulation of blood pressurepositive regulation of cytokine secretioncellular response to dexamethasone stimuluspositive regulation of branching involved in ureteric bud morphogenesissignal transduction
It has to be done as per old AB suggested Products section.
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